Maaser Sheni, Chapter Five, Mishnah Eight
Rabbi Judah said: in early times they used to send to householders in the provinces [saying:] Hasten to set right your produce before the time of removal arrives, until Rabbi Akiva came and taught that all produce which has not reached the time of tithing is exempt from the removal.
Before Rabbi Akiva, rabbis used to send messages to people all over the provinces of Israel warning them that they should hurry up and separate terumah and all tithes from their produce before the time to remove them from the home comes around. Furthermore, they wont be able to do the confession over tithes (Deuteronomy 26:12-15) until they separate all the tithes from their produce.
This all changed when Rabbi Akiva taught that all produce that has not reached the time when it must be tithed need not be removed from the home. These times were explicated in Maasrot 1:2-4.